Chemicals and Drugs

alpha-Endorphin

An endogenous opioid peptide derived from BETA-LIPOTROPIN of the pro-opiomelanocortin (POMC) system. It is the 16-amino acid sequence of the N-terminal of BETA-ENDORPHIN and differs from GAMMA-ENDORPHIN by one amino acid (beta-endorphin 1-17).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An endogenous opioid peptide derived from BETA-LIPOTROPIN of the pro-opiomelanocortin (POMC) system. It is the 16-amino acid sequence of the N-terminal of BETA-ENDORPHIN and differs from GAMMA-ENDORPHIN by one amino acid (beta-endorphin 1-17).

Chemical Identity

Chemical Information

Molecular Formula
C77H120N18O26S
Molecular Weight
1745.9 g/mol
CAS Registry No.
61512-76-3
IUPAC Name
(4S)-5-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S,3R)-1-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-hydroxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoic acid
InChIKey
NXSIJWJXMWBCBX-NWKQFZAZSA-N
SMILES
C[C@H]([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CNC(=O)CNC(=O)[C@H](CC3=CC=C(C=C3)O)N)O
MeSH Unique ID
D018822
Source
PubChem CID 16138308

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

3 entry terms
  • Endorphin, alpha
  • beta-Endorphin (1-16)
  • alpha Endorphin

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

95; was ALPHA-ENDORPHIN (NM) 1980-94

MeSH Record

Previous Indexing

  • Opioid Peptides (1980-1994)

MeSH Hierarchy

Tree Numbers

  1. D06.472w.699w.327.935.119w
  2. D06.472w.699w.631.525.600.119w
  3. D12.644w.400w.400.935.119w
  4. D12.644w.400w.575w.241w.039w
  5. D12.644w.548w.365.935.119w
  6. D12.644w.548w.691.525.690.119w
  7. D12.776w.631w.650w.405.935.119w
  8. D12.776w.631w.650w.575w.241w.040w

AMA Style

References

  1. National Library of Medicine. alpha-Endorphin. Medical Subject Headings (MeSH). 2026. Unique ID D018822. http://id.nlm.nih.gov/mesh/2026/D018822
  2. alpha-Endorphin. In: Wikipedia. https://en.wikipedia.org/wiki/%CE%91-Endorphin
  3. alpha-Endorphin. In: Wikidata. https://www.wikidata.org/wiki/Q4734927
  4. alpha-Endorphin. In: PubChem Compound. CID 16138308. https://pubchem.ncbi.nlm.nih.gov/compound/16138308