Phenomena and Processes

cGAS-STING Signaling Pathway

A signal transduction pathway that involves cGMP-AMP synthase (cGAS), stimulator of interferon genes (STING), and downstream signaling adaptors. This pathway plays an essential role in the innate immune system by activating immune defenses, particularly against invading pathogens or harmful damage.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A signal transduction pathway that involves cGMP-AMP synthase (cGAS), stimulator of interferon genes (STING), and downstream signaling adaptors. This pathway plays an essential role in the innate immune system by activating immune defenses, particularly against invading pathogens or harmful damage.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

7 entry terms
  • (cGAS-STING) Pathway
  • cGAS-STING Signaling
  • cGAS-STING cascade
  • cGAS–STING Cytosolic DNA Sensing Pathway
  • cGAS-STING Activation
  • cGAS-STING Immunity Pathway
  • cGAS-STING Innate Immunity Pathway

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2026

MeSH Record

Previous Indexing

  • Signal Transduction (2015-2025)

MeSH Hierarchy

Tree Numbers

  1. G02.111.820w.926w
  2. G04.835w.926w

AMA Style

References

  1. National Library of Medicine. cGAS-STING Signaling Pathway. Medical Subject Headings (MeSH). 2026. Unique ID D000099196. http://id.nlm.nih.gov/mesh/2026/D000099196
  2. cGAS-STING Signaling Pathway. In: Wikipedia. https://en.wikipedia.org/wiki/CGAS%E2%80%93STING_cytosolic_DNA_sensing_pathway
  3. cGAS-STING Signaling Pathway. In: Wikidata. https://www.wikidata.org/wiki/Q25323740