Chemicals and Drugs

gamma-Endorphin

An endogenous opioid peptide derived from BETA-LIPOTROPIN of the pro-opiomelanocortin (POMC) system. It is the 17-amino acid sequence of the N-terminal of BETA-ENDORPHIN and differs from ALPHA-ENDORPHIN by one amino acid (beta-endorphin 1-16).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An endogenous opioid peptide derived from BETA-LIPOTROPIN of the pro-opiomelanocortin (POMC) system. It is the 17-amino acid sequence of the N-terminal of BETA-ENDORPHIN and differs from ALPHA-ENDORPHIN by one amino acid (beta-endorphin 1-16).

Chemical Identity

Chemical Information

Molecular Formula
C83H131N19O27S
Molecular Weight
1859.1 g/mol
CAS Registry No.
61512-77-4
IUPAC Name
(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoic acid
InChIKey
GASYAMBJHBRTOE-WHDBNHDESA-N
SMILES
C[C@H]([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CNC(=O)CNC(=O)[C@H](CC3=CC=C(C=C3)O)N)O
MeSH Unique ID
D018823
Source
PubChem CID 16138008

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

3 entry terms
  • Endorphin, gamma
  • beta-Endorphin (1-17)
  • gamma Endorphin

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

95; was GAMMA-ENDORPHIN (NM) 1980-94

MeSH Record

Previous Indexing

  • Opioid Peptides (1980-1994)

MeSH Hierarchy

Tree Numbers

  1. D06.472w.699w.327.935.505w
  2. D06.472w.699w.631.525.600.505w
  3. D12.644w.400w.400.935.505w
  4. D12.644w.400w.575w.241w.540w
  5. D12.644w.548w.365.935.505w
  6. D12.644w.548w.691.525.690.505w
  7. D12.776w.631w.650w.405.935.505w
  8. D12.776w.631w.650w.575w.241w.540w

AMA Style

References

  1. National Library of Medicine. gamma-Endorphin. Medical Subject Headings (MeSH). 2026. Unique ID D018823. http://id.nlm.nih.gov/mesh/2026/D018823
  2. gamma-Endorphin. In: Wikipedia. https://en.wikipedia.org/wiki/%CE%93-Endorphin
  3. gamma-Endorphin. In: Wikidata. https://www.wikidata.org/wiki/Q5520266
  4. gamma-Endorphin. In: PubChem Compound. CID 16138008. https://pubchem.ncbi.nlm.nih.gov/compound/16138008