Chemicals and Drugs

gamma-Glutamylcyclotransferase

An enzyme that catalyzes the synthesis of pyroglutamate from a gamma-glutamyl-amino acid, also releasing the free amino acid. The enzyme acts on derivatives of glutamate, 2-aminobutyrate, alanine and glycine. The enzyme has been proposed to have a role in a gamma-glutamyl cycle for amino acid transport into cells in the intestines. EC 2.3.2.4.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An enzyme that catalyzes the synthesis of pyroglutamate from a gamma-glutamyl-amino acid, also releasing the free amino acid. The enzyme acts on derivatives of glutamate, 2-aminobutyrate, alanine and glycine. The enzyme has been proposed to have a role in a gamma-glutamyl cycle for amino acid transport into cells in the intestines. EC 2.3.2.4.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

4 entry terms
  • gamma-Glutamylamine Cyclotransferase
  • Cyclotransferase, gamma-Glutamylamine
  • gamma Glutamylamine Cyclotransferase
  • gamma Glutamylcyclotransferase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

do not confuse with GAMMA-GLUTAMYLTRANSFERASE

MeSH Record

History Note

91(75); was see under ACYLTRANSFERASES 1975-90

MeSH Record

Previous Indexing

  • Acyltransferases (1970-1974)
  • Glutamates (1970-1974)
  • Pyrrolidonecarboxylic Acid (1972-1974)

MeSH Hierarchy

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AMA Style

References

  1. National Library of Medicine. gamma-Glutamylcyclotransferase. Medical Subject Headings (MeSH). 2026. Unique ID D005722. http://id.nlm.nih.gov/mesh/2026/D005722
  2. gamma-Glutamylcyclotransferase. In: Wikipedia. https://en.wikipedia.org/wiki/Gamma-glutamylcyclotransferase
  3. gamma-Glutamylcyclotransferase. In: Wikidata. https://www.wikidata.org/wiki/Q3757999