Structured Summary
Abstract
A subclass of crystallins expressed highly in lens of diurnal Australian MARSUPIALS and in neural tissue, muscle, and kidney in humans. It is not a structural protein accounting for the transparency of the human lens unlike other crystallins but instead plays a role in thyroid hormone bioavailability. It is also a cerebral ketimine reductase which reduces cyclic imines (e.g., DELTA(1)-PIPERIDINE-2-CARBOXYLIC ACID; CYSTATHIONINE KETIMINE and LANTHIONINE KETIMINE) in mammalian brain. Mutations in mu-crystallins are associated with an autosomal dominant NONSYNDROMIC DEAFNESS.
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
Drag nodes to rearrange; hover to trace links; click a node to open its page.
MeSH Record
Synonyms
13 entry terms
- CRYM Protein
- Crystallin mu
- Ketimine Reductase mu-Crystallin
- NADP-Regulated Thyroid Hormone Binding Protein
- THBP Protein
- Ketimine Reductase mu Crystallin
- NADP Regulated Thyroid Hormone Binding Protein
- Protein, CRYM
- Protein, THBP
- Reductase mu-Crystallin, Ketimine
- mu Crystallins
- mu, Crystallin
- mu-Crystallin, Ketimine Reductase
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2022(1992)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. mu-Crystallins. Medical Subject Headings (MeSH). 2026. Unique ID D000090803. http://id.nlm.nih.gov/mesh/2026/D000090803
- mu-Crystallins. In: Wikidata. https://www.wikidata.org/wiki/Q111327732