Chemicals and Drugs

omega-Agatoxin IVA

A neuropeptide toxin from the venom of the funnel web spider, Agelenopsis aperta. It inhibits CALCIUM CHANNELS, P-TYPE by altering the voltage-dependent gating so that very large depolarizations are needed for channel opening. It also inhibits CALCIUM CHANNELS, Q-TYPE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A neuropeptide toxin from the venom of the funnel web spider, Agelenopsis aperta. It inhibits CALCIUM CHANNELS, P-TYPE by altering the voltage-dependent gating so that very large depolarizations are needed for channel opening. It also inhibits CALCIUM CHANNELS, Q-TYPE.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

4 entry terms
  • omega-Aga-IVA
  • IVA, omega-Agatoxin
  • omega Aga IVA
  • omega Agatoxin IVA

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, enzymology, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, therapeutic use, toxicity, urine.

MeSH Record

History Note

2000; use OMEGA-AGATOXIN IVA (NM) 1992-1999

MeSH Record

Previous Indexing

  • Spider Venoms (1992-1999)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.400w.562
  2. D12.776w.093.249w.500
  3. D20.888w.065.870.324w.500
  4. D23.946w.833w.065.870.324w.500

AMA Style

References

  1. National Library of Medicine. omega-Agatoxin IVA. Medical Subject Headings (MeSH). 2026. Unique ID D020867. http://id.nlm.nih.gov/mesh/2026/D020867
  2. omega-Agatoxin IVA. In: Wikidata. https://www.wikidata.org/wiki/Q72436851