Structured Summary
Abstract
A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.
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Synonyms
34 entry terms
- ROCK Protein Kinases
- ROK Kinase
- rho-Associated Coiled-Coil Kinase
- rho-Associated Kinase
- rho-Kinase
- Coiled-Coil Kinase, rho-Associated
- Protein Kinases, ROCK
- rho Associated Coiled Coil Kinase
- rho Associated Kinase
- rho Associated Kinases
- rho Kinase
- ROCK-I Protein Kinase
- ROCK-II Protein Kinase
- p160 rhoA-Binding Kinase ROKalpha
- p160ROCK
- rho-Associated Coiled-Coil Containing Protein Kinase 1
- rho-Associated Coiled-Coil Containing Protein Kinase 2
- rho-Associated Kinase 1
- rho-Associated Kinase 2
- rho-Associated Kinase alpha
- rho-Associated Kinase beta
- rho-Associated Protein Kinase alpha
- rho-Associated Protein Kinase beta
- ROCK I Protein Kinase
- ROCK II Protein Kinase
- p160 rhoA Binding Kinase ROKalpha
- rho Associated Coiled Coil Containing Protein Kinase 1
- rho Associated Coiled Coil Containing Protein Kinase 2
- rho Associated Kinase 1
- rho Associated Kinase 2
- rho Associated Kinase alpha
- rho Associated Kinase beta
- rho Associated Protein Kinase alpha
- rho Associated Protein Kinase beta
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2008
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References
- National Library of Medicine. rho-Associated Kinases. Medical Subject Headings (MeSH). 2026. Unique ID D054460. http://id.nlm.nih.gov/mesh/2026/D054460
- rho-Associated Kinases. In: Wikipedia. https://en.wikipedia.org/wiki/Rho-associated_protein_kinase
- rho-Associated Kinases. In: Wikidata. https://www.wikidata.org/wiki/Q24721770