Chemicals and Drugs

von Willebrand Factor

A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.

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Classification

Broader headings

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See Also

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Synonyms

11 entry terms
  • Factor VIII-Related Antigen
  • Factor VIIIR-Ag
  • Factor VIIIR-RCo
  • Ristocetin Cofactor
  • Ristocetin-Willebrand Factor
  • von Willebrand Protein
  • Factor VIII Related Antigen
  • Factor VIIIR Ag
  • Factor VIIIR RCo
  • Ristocetin Willebrand Factor
  • Plasma Factor VIII Complex

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

/ defic = VON WILLEBRAND DISEASE or specific type of Von Willebrand Disease

MeSH Record

History Note

86(76); was see under BLOOD COAGULATION FACTORS 1976-85; FACTOR VIII RELATED ANTIGEN, previously in the Supplementary Chemical File, was mapped to both FACTOR VIII & ANTIGENS 1977-89

MeSH Record

Previous Indexing

  • Blood Coagulation Factors (1966-1974)
  • Blood Platelets (1966-1974)
  • von Willebrand's Disease (1966-1975)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.124w.125.920w
  2. D23.119.985w

MeSH Record

NLM Classification

WH 310

AMA Style

References

  1. National Library of Medicine. von Willebrand Factor. Medical Subject Headings (MeSH). 2026. Unique ID D014841. http://id.nlm.nih.gov/mesh/2026/D014841
  2. von Willebrand Factor. In: Wikipedia. https://en.wikipedia.org/wiki/Von_Willebrand_factor
  3. von Willebrand Factor. In: Wikidata. https://www.wikidata.org/wiki/Q412310