Structured Summary
Abstract
A progressive neurodegenerative disorder that begins with muscle weakness, then progresses to startle reaction, retardation and seizures. It is characterized by the accumulation of G(M2) GANGLIOSIDE in neurons that is caused by a lack of G(M2) ACTIVATOR PROTEIN function. The AB variant designation refers to the increase of both HEXOSAMINIDASE A and HEXOSAMINIDASE B in tissues that lack of G(M2) activator protein.
MeSH Record
Classification
Broader headings
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MeSH Record
Synonyms
38 entry terms
- AB Variant GM2-Gangliosidosis
- AB Variant Gangliosidosis GM2
- Activator Deficiency GM2 Gangliosidosis
- Activator-Deficient Tay-Sachs Disease
- Deficiency Disease, GM2 Protein Activator
- GM2 Activator Deficiency
- GM2 Activator Deficiency Disease
- GM2 Gangliosidosis, Type AB
- GM2 Protein Activator Deficiency Disease
- GM2-Gangliosidosis, AB Variant
- Gangliosidosis GM2, AB Variant
- Gangliosidosis GM2, Type AB
- Hexosaminidase Activator Deficiency
- Hexosaminidase Activator Protein Deficiency Disease
- Tay-Sachs Disease, AB Variant
- AB Variant GM2 Gangliosidosis
- AB Variant GM2-Gangliosidoses
- Activator Deficiencies, GM2
- Activator Deficiencies, Hexosaminidase
- Activator Deficiency, GM2
- Activator Deficiency, Hexosaminidase
- Activator Deficient Tay Sachs Disease
- Activator-Deficient Tay-Sachs Diseases
- Deficiencies, GM2 Activator
- Deficiencies, Hexosaminidase Activator
- Deficiency, GM2 Activator
- Deficiency, Hexosaminidase Activator
- Disease, Activator-Deficient Tay-Sachs
- Diseases, Activator-Deficient Tay-Sachs
- GM2 Activator Deficiencies
- GM2 Gangliosidosis, AB Variant
- GM2-Gangliosidoses, AB Variant
- Hexosaminidase Activator Deficiencies
- Tay Sachs Disease, AB Variant
- Tay-Sachs Disease, Activator-Deficient
- Tay-Sachs Diseases, Activator-Deficient
- Variant GM2-Gangliosidoses, AB
- Variant GM2-Gangliosidosis, AB
MeSH Record
Aspects Covered
34 allowable subheadings
Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.
MeSH Record
History Note
2005(2000); use GANGLIOSIDOSES GM2 2000-2004
MeSH Record
Previous Indexing
- Gangliosidoses (2000-2004)
MeSH Hierarchy
Tree Numbers
- C10w.228w.140w.163.100.435.825w.300w.300w.750w
- C16w.320w.565w.189.435.825w.300w.300w.750w
- C16w.320w.565w.398w.641w.803w.350w.300w.925w
- C16w.320w.565w.595w.554.825w.300w.300w.920w
- C18.452w.132.100.435.825w.300w.300w.750w
- C18.452w.584w.563w.641w.803w.350w.300w.925w
- C18.452w.648w.189.435.825w.300w.300w.750w
- C18.452w.648w.398w.641w.803w.350w.300w.925w
- C18.452w.648w.595w.554.825w.300w.300w.920w
AMA Style
References
- National Library of Medicine. AB Variant Tay-Sachs Disease. Medical Subject Headings (MeSH). 2026. Unique ID D049290. http://id.nlm.nih.gov/mesh/2026/D049290
- AB Variant Tay-Sachs Disease. In: Wikipedia. https://en.wikipedia.org/wiki/GM2-gangliosidosis,_AB_variant
- AB Variant Tay-Sachs Disease. In: Wikidata. https://www.wikidata.org/wiki/Q5513688