Chemicals and Drugs

ADAMTS Proteins

A subfamily of ADAM proteases that are distinguished by the presence of one or more THROMBOSPONDIN type-1 repeats (TSRs). These are three-strand motifs that contain characteristic TRYPTOPHAN, ARGININE, and CYSTEINE residues respectively. In contrast to ADAM proteins, which reside on CELL MEMBRANES, ADAMTS proteases are secreted and function in the EXTRACELLULAR MATRIX.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A subfamily of ADAM proteases that are distinguished by the presence of one or more THROMBOSPONDIN type-1 repeats (TSRs). These are three-strand motifs that contain characteristic TRYPTOPHAN, ARGININE, and CYSTEINE residues respectively. In contrast to ADAM proteins, which reside on CELL MEMBRANES, ADAMTS proteases are secreted and function in the EXTRACELLULAR MATRIX.

MeSH Record

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MeSH Record

Synonyms

17 entry terms
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs Protein
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs Proteins
  • ADAMTS Protease
  • ADAMTS Proteases
  • ADAMTS Protein
  • Adam Metallopeptidases With Thrombospondin Type 1 Motif Protein
  • Adam Metallopeptidases With Thrombospondin Type 1 Motif Proteins
  • Protease, ADAMTS
  • Protein, ADAMTS
  • ADAMTS-Like Protein
  • ADAMTS-Like Proteins
  • ADAMTSL Protein
  • ADAMTSL Proteins
  • ADAMTS Like Protein
  • ADAMTS Like Proteins
  • Protein, ADAMTS-Like
  • Protein, ADAMTSL

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • ADAM Proteins (2006-2016)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.656w.675w.374w.102w.500w
  2. D09w.400w.430w.500w.500w
  3. D12.776w.395w.033w.500w
  4. D12.776w.860w.300.085w

AMA Style

References

  1. National Library of Medicine. ADAMTS Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D000071096. http://id.nlm.nih.gov/mesh/2026/D000071096
  2. ADAMTS Proteins. In: Wikipedia. https://en.wikipedia.org/wiki/ADAMTS
  3. ADAMTS Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q102253084