Chemicals and Drugs

Abciximab

A Fab fragment of the chimeric monoclonal antibody 7E3 that binds to the glycoprotein IIb-IIIa receptor of human platelets, and blocks PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX, potently inhibiting PLATELET AGGREGATION. It is used in treatment of refractory unstable angina, and for prevention of ischemic complications in patients undergoing percutaneous coronary procedures such as ANGIOPLASTY; ATHERECTOMY; or stenting.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A Fab fragment of the chimeric monoclonal antibody 7E3 that binds to the glycoprotein IIb-IIIa receptor of human platelets, and blocks PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX, potently inhibiting PLATELET AGGREGATION. It is used in treatment of refractory unstable angina, and for prevention of ischemic complications in patients undergoing percutaneous coronary procedures such as ANGIOPLASTY; ATHERECTOMY; or stenting.

Chemical Identity

Chemical Information

Molecular Formula
C22H27ClN4O3S
Molecular Weight
463.0 g/mol
IUPAC Name
4-[[2-[1-(4-chloro-2,5-dimethylphenyl)sulfonylpiperidin-4-yl]imidazol-1-yl]methyl]-3,5-dimethyl-1,2-oxazole
InChIKey
WXEDUKRNQGUVRZ-UHFFFAOYSA-N
SMILES
CC1=CC(=C(C=C1Cl)C)S(=O)(=O)N2CCC(CC2)C3=NC=CN3CC4=C(ON=C4C)C
MeSH Unique ID
D000077284
Source
PubChem CID 3815015

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

6 entry terms
  • Chimeric 7E3 Fab
  • c7E3 Fab
  • Fab, Chimeric 7E3
  • CentoRx
  • Clotinab
  • ReoPro

MeSH Record

Aspects Covered

24 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2019 (1994)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.541.500.650w.125w
  2. D12.776w.124w.486.485.114w.224w.060w.125w
  3. D12.776w.124w.486.485.680.650w.125w
  4. D12.776w.124w.790.651.114w.224w.060w.125w
  5. D12.776w.124w.790.651.680.650w.125w
  6. D12.776w.377w.715.548.114w.224w.200w.125w
  7. D12.776w.377w.715.548.680.650w.125w

AMA Style

References

  1. National Library of Medicine. Abciximab. Medical Subject Headings (MeSH). 2026. Unique ID D000077284. http://id.nlm.nih.gov/mesh/2026/D000077284
  2. Abciximab. In: Wikipedia. https://en.wikipedia.org/wiki/Abciximab
  3. Abciximab. In: Wikidata. https://www.wikidata.org/wiki/Q307088
  4. Abciximab. In: PubChem Compound. CID 3815015. https://pubchem.ncbi.nlm.nih.gov/compound/3815015