Structured Summary
Abstract
Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
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Classification
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Drug Class
Pharmacological Action
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Synonyms
13 entry terms
- Fab Fragment
- Fab Fragments
- Fab Immunoglobulin Fragments
- Ig Fab Fragments
- Immunoglobulin Fab Fragment
- Immunoglobulins, Fab
- Immunoglobulins, Fab Fragment
- Fab Fragment Immunoglobulins
- Fab Fragment, Immunoglobulin
- Fab Fragments, Immunoglobulin
- Fragment Immunoglobulins, Fab
- Fragment, Fab
- Immunoglobulin Fragments, Fab
MeSH Record
Aspects Covered
23 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2006 (1973)
MeSH Record
Previous Indexing
- Immunoglobulins (1970-1972)
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AMA Style
References
- National Library of Medicine. Immunoglobulin Fab Fragments. Medical Subject Headings (MeSH). 2026. Unique ID D007140. http://id.nlm.nih.gov/mesh/2026/D007140
- Immunoglobulin Fab Fragments. In: Wikipedia. https://en.wikipedia.org/wiki/Fragment_antigen-binding_region
- Immunoglobulin Fab Fragments. In: Wikidata. https://www.wikidata.org/wiki/Q909628