Chemicals and Drugs

Tuftsin

N(2)-((1-(N(2)-L-Threonyl)-L-lysyl)-L-prolyl)-L-arginine. A tetrapeptide produced in the spleen by enzymatic cleavage of a leukophilic gamma-globulin. It stimulates the phagocytic activity of blood polymorphonuclear leukocytes and neutrophils in particular. The peptide is located in the Fd fragment of the gamma-globulin molecule.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

N(2)-((1-(N(2)-L-Threonyl)-L-lysyl)-L-prolyl)-L-arginine. A tetrapeptide produced in the spleen by enzymatic cleavage of a leukophilic gamma-globulin. It stimulates the phagocytic activity of blood polymorphonuclear leukocytes and neutrophils in particular. The peptide is located in the Fd fragment of the gamma-globulin molecule.

Chemical Identity

Chemical Information

Molecular Formula
C21H40N8O6
Molecular Weight
500.6 g/mol
CAS Registry No.
9063-57-4
IUPAC Name
(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
InChIKey
IESDGNYHXIOKRW-YXMSTPNBSA-N
SMILES
C[C@H]([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)N)O
MeSH Unique ID
D014405
Source
PubChem CID 156080

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

3 entry terms
  • L-Thr-L-Lys-L-Pro-L-Arg
  • L-Threonyl-L-Lysyl-L-Prolyl-L-Arginine
  • Taftsin

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

84(75); was see under IMMUNOGLOBULINS, FD 1975-83; LEUKOKININ (with LEUCOKININ a see ref to it) was see under GAMMA GLOBULINS 1975-83; LEUKOKININ & LEUCOKININ were see TUFTSIN 1984-93

MeSH Record

Previous Indexing

  • Immunoglobulin Fragments (1973-1974)
  • Oligopeptides (1973-1974)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.456w.840w
  2. D12.644w.541.500.650w.750w
  3. D12.776w.124w.486.485.397w.500w
  4. D12.776w.124w.486.485.680.650w.750w
  5. D12.776w.124w.790.651.397w.500w
  6. D12.776w.124w.790.651.680.650w.750w
  7. D12.776w.377w.715.548.397w.500w
  8. D12.776w.377w.715.548.680.650w.750w

AMA Style

References

  1. National Library of Medicine. Tuftsin. Medical Subject Headings (MeSH). 2026. Unique ID D014405. http://id.nlm.nih.gov/mesh/2026/D014405
  2. Tuftsin. In: Wikipedia. https://en.wikipedia.org/wiki/Tuftsin
  3. Tuftsin. In: Wikidata. https://www.wikidata.org/wiki/Q414250
  4. Tuftsin. In: PubChem Compound. CID 156080. https://pubchem.ncbi.nlm.nih.gov/compound/156080