Chemicals and Drugs

Acedapsone

Acetylated sulfone that is slowly metabolized to give long-term, low blood levels of DAPSONE. It has antimicrobial and antimalarial action, but is mainly used as a depot leprostatic agent.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Acetylated sulfone that is slowly metabolized to give long-term, low blood levels of DAPSONE. It has antimicrobial and antimalarial action, but is mainly used as a depot leprostatic agent.

Chemical Identity

Chemical Information

Molecular Formula
C16H16N2O4S
Molecular Weight
332.4 g/mol
CAS Registry No.
77-46-3
IUPAC Name
N-[4-(4-acetamidophenyl)sulfonylphenyl]acetamide
InChIKey
AMTPYFGPPVFBBI-UHFFFAOYSA-N
SMILES
CC(=O)NC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C
MeSH Unique ID
D000072
Source
PubChem CID 6477

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • 4',4'''-Sulfonylbis(acetanilide)
  • 4,4'-Diacetyldiaminodiphenylsulfone
  • Acetyldiphenazonum
  • DADDS
  • Diacetyldapsone
  • Sulfadiamine
  • 4,4' Diacetyldiaminodiphenylsulfone
  • Hansolar
  • Rodilone

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(76); was see under DAPSONE 1976-90

MeSH Record

Previous Indexing

  • Acetamides (1975)
  • Acetanilides (1972-1974)
  • Dapsone/analogs & derivatives (1975)
  • Sulfones (1972-1974)

MeSH Hierarchy

Tree Number

  1. D02w.886w.590w.263w.050w

AMA Style

References

  1. National Library of Medicine. Acedapsone. Medical Subject Headings (MeSH). 2026. Unique ID D000072. http://id.nlm.nih.gov/mesh/2026/D000072
  2. Acedapsone. In: Wikipedia. https://en.wikipedia.org/wiki/Acedapsone
  3. Acedapsone. In: Wikidata. https://www.wikidata.org/wiki/Q2823819
  4. Acedapsone. In: PubChem Compound. CID 6477. https://pubchem.ncbi.nlm.nih.gov/compound/6477