Chemicals and Drugs

Dapsone

A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)

Chemical Identity

Chemical Information

Molecular Formula
C12H12N2O2S
Molecular Weight
248.30 g/mol
CAS Registry No.
80-08-0
IUPAC Name
4-(4-aminophenyl)sulfonylaniline
InChIKey
MQJKPEGWNLWLTK-UHFFFAOYSA-N
SMILES
C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N
MeSH Unique ID
D003622
Source
PubChem CID 2955

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

12 entry terms
  • 4,4'-Diaminophenyl Sulfone
  • DADPS
  • Diaminodiphenylsulfone
  • Diaphenylsulfone
  • Sulfonyldianiline
  • 4,4' Diaminophenyl Sulfone
  • Sulfone, 4,4'-Diaminophenyl
  • Avlosulfone
  • Dapsoderm-X
  • Dapson-Fatol
  • Disulone
  • Sulfona

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Hierarchy

Tree Number

  1. D02w.886w.590w.263w

MeSH Record

NLM Classification

QV 259

AMA Style

References

  1. National Library of Medicine. Dapsone. Medical Subject Headings (MeSH). 2026. Unique ID D003622. http://id.nlm.nih.gov/mesh/2026/D003622
  2. Dapsone. In: Wikipedia. https://en.wikipedia.org/wiki/Dapsone
  3. Dapsone. In: Wikidata. https://www.wikidata.org/wiki/Q422226
  4. Dapsone. In: PubChem Compound. CID 2955. https://pubchem.ncbi.nlm.nih.gov/compound/2955