Chemicals and Drugs

Activin Receptors

Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). Activin receptors also bind TRANSFORMING GROWTH FACTOR BETA. As those transmembrane receptors of the TGF-beta superfamily (RECEPTORS, TRANSFORMING GROWTH FACTOR BETA), ALK's consist of two different but related protein kinases, Type I and Type II. Activins initiate cellular signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS, TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS, TYPE I ) with subsequent activation of the type I kinase activity.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). Activin receptors also bind TRANSFORMING GROWTH FACTOR BETA. As those transmembrane receptors of the TGF-beta superfamily (RECEPTORS, TRANSFORMING GROWTH FACTOR BETA), ALK's consist of two different but related protein kinases, Type I and Type II. Activins initiate cellular signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS, TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS, TYPE I ) with subsequent activation of the type I kinase activity.

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MeSH Record

Synonyms

11 entry terms
  • Activin Receptor
  • Activin Receptor-Like Kinases
  • Activin Receptor-like Kinase
  • Receptor, Activin
  • Activin Receptor Like Kinases
  • Activin Receptor like Kinase
  • Kinase, Activin Receptor-like
  • Kinases, Activin Receptor-Like
  • Receptor-Like Kinases, Activin
  • Receptor-like Kinase, Activin
  • Receptors, Activin

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2002(1991)

MeSH Record

Previous Indexing

  • Protein-Serine-Threonine Kinases (1993-2001)
  • Receptors, Cell Surface (1989-1992)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.700w.062w
  2. D12.776w.476.563w.062w
  3. D12.776w.543w.750w.750w.400w.820w.500w

AMA Style

References

  1. National Library of Medicine. Activin Receptors. Medical Subject Headings (MeSH). 2026. Unique ID D029404. http://id.nlm.nih.gov/mesh/2026/D029404
  2. Activin Receptors. In: Wikipedia. https://en.wikipedia.org/wiki/Activin_receptor
  3. Activin Receptors. In: Wikidata. https://www.wikidata.org/wiki/Q4677603