Structured Summary
Abstract
Changes in the ANTIGEN population by slow and minor (antigenic drift) or sudden and major mutations (antigenic shift). Accumulation of minor mutations in antigenic drift over time may require development of new vaccine (e.g., seasonal FLU VACCINES). Antigenic shift on the other hand is less common but may result in emergence of a new subtype or species and sometimes pandemics (e.g., H1N1 pandemics in 2009 and 2018 and COVID-19) due to lack of HERD IMMUNITY to the newly emerged novel pathogen.
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Classification
Broader headings
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Synonyms
15 entry terms
- Antigen Drift and Shift
- Antigen Shift and Drift
- Antigenic Shift and Drift
- Antigen Drift
- Antigen Escape
- Antigen Shift
- Antigenic Drift
- Antigenic Escape
- Antigenic Shift
- Drift, Antigen
- Drift, Antigenic
- Escape, Antigen
- Escape, Antigenic
- Shift, Antigen
- Shift, Antigenic
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Aspects Covered
5 allowable subheadings
Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.
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History Note
2022
MeSH Record
Previous Indexing
- Antigenic Variation (1990-2021)
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AMA Style
References
- National Library of Medicine. Antigenic Drift and Shift. Medical Subject Headings (MeSH). 2026. Unique ID D000088603. http://id.nlm.nih.gov/mesh/2026/D000088603
- Antigenic Drift and Shift. In: Wikidata. https://www.wikidata.org/wiki/Q112062735