Phenomena and Processes

Antigenic Variation

Change in the surface ANTIGEN of a microorganism. There are two different types. One is a phenomenon, especially associated with INFLUENZA VIRUSES, where they undergo spontaneous variation both as slow antigenic drift and sudden emergence of new strains (antigenic shift). The second type is when certain PARASITES, especially trypanosomes, PLASMODIUM, and BORRELIA, survive the immune response of the host by changing the surface coat (antigen switching). (From Herbert et al., The Dictionary of Immunology, 4th ed)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Change in the surface ANTIGEN of a microorganism. There are two different types. One is a phenomenon, especially associated with INFLUENZA VIRUSES, where they undergo spontaneous variation both as slow antigenic drift and sudden emergence of new strains (antigenic shift). The second type is when certain PARASITES, especially trypanosomes, PLASMODIUM, and BORRELIA, survive the immune response of the host by changing the surface coat (antigen switching). (From Herbert et al., The Dictionary of Immunology, 4th ed)

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Classification

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Synonyms

11 entry terms
  • Antigen Variation
  • Antigenic Variability
  • Variation, Antigenic
  • Variability, Antigenic
  • Variation, Antigen
  • Antigen Switching
  • Antigenic Diversity
  • Antigenic Switching
  • Switching, Antigenic
  • Diversity, Antigenic
  • Switching, Antigen

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

Indexing Annotation

microbes only; ANTIBODY DIVERSITY is also available

MeSH Record

History Note

1988

MeSH Record

Previous Indexing

  • Antigenic Determinants (1975-1987)
  • Genetics, Microbial (1973-1987)
  • Variation (Genetics) (1966-1987)

MeSH Hierarchy

Tree Numbers

  1. G05.365w.073w
  2. G12.500.249w

AMA Style

References

  1. National Library of Medicine. Antigenic Variation. Medical Subject Headings (MeSH). 2026. Unique ID D000940. http://id.nlm.nih.gov/mesh/2026/D000940
  2. Antigenic Variation. In: Wikipedia. https://en.wikipedia.org/wiki/Antigenic_variation
  3. Antigenic Variation. In: Wikidata. https://www.wikidata.org/wiki/Q4774739