Structured Summary
Abstract
A CARD signaling adaptor protein characterized by an N-terminal CARD DOMAIN and C-terminal WD40 REPEATS. It plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY) and binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX which activates INITIATOR CASPASES such as CASPASE 9.
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Synonyms
5 entry terms
- Apaf-1 Protease-Activating Factor
- Apoptotic Peptidase Activating Factor 1
- Apaf 1 Protease Activating Factor
- Apoptotic Protease Activating Factor 1
- Protease-Activating Factor, Apaf-1
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Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2007(1997)
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AMA Style
References
- National Library of Medicine. Apoptotic Protease-Activating Factor 1. Medical Subject Headings (MeSH). 2026. Unique ID D053477. http://id.nlm.nih.gov/mesh/2026/D053477
- Apoptotic Protease-Activating Factor 1. In: Wikidata. https://www.wikidata.org/wiki/Q24770256