Chemicals and Drugs

Astemizole

Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.

Chemical Identity

Chemical Information

Molecular Formula
C28H31FN4O
Molecular Weight
458.6 g/mol
CAS Registry No.
68844-77-9
IUPAC Name
1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl]benzimidazol-2-amine
InChIKey
GXDALQBWZGODGZ-UHFFFAOYSA-N
SMILES
COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
MeSH Unique ID
D016589
Source
PubChem CID 2247

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

24 entry terms
  • Alermizol
  • Astemina
  • Astemizol Alonga
  • Astemizol Ratiopharm
  • Astesen
  • Emdar
  • Esmacen
  • Fustermizol
  • Hismanal
  • Histaminos
  • Hubermizol
  • Laridal
  • Paralergin
  • R-43-512
  • Retolen
  • Rifedot
  • Rimbol
  • Romadin
  • Simprox
  • Urdrim
  • Alonga, Astemizol
  • R 43 512
  • R43512
  • Ratiopharm, Astemizol

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

92; was ASTEMIZOLE (NM) 1981-91

MeSH Record

Previous Indexing

  • Benzimidazoles (1966-1991)
  • Histamine H1 Receptor Blockaders (1966-1991)

MeSH Hierarchy

Tree Number

  1. D03w.633.100.103.105w

AMA Style

References

  1. National Library of Medicine. Astemizole. Medical Subject Headings (MeSH). 2026. Unique ID D016589. http://id.nlm.nih.gov/mesh/2026/D016589
  2. Astemizole. In: Wikipedia. https://en.wikipedia.org/wiki/Astemizole
  3. Astemizole. In: Wikidata. https://www.wikidata.org/wiki/Q423437
  4. Astemizole. In: PubChem Compound. CID 2247. https://pubchem.ncbi.nlm.nih.gov/compound/2247