Chemicals and Drugs

Non-Sedating Histamine H1 Antagonists

A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.

MeSH Record

Classification

Broader headings

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See Also

MeSH Record

Synonyms

14 entry terms
  • H1 Antihistamines, Non-Sedating
  • Histamine H1 Antagonists, Non-Sedating
  • Second Generation Antihistamine
  • Second Generation Antihistamines
  • Second Generation H1 Antagonist
  • Second Generation H1 Antagonists
  • Antihistamine, Second Generation
  • Antihistamines, Second Generation
  • Generation Antihistamine, Second
  • H1 Antihistamines, Non Sedating
  • Histamine H1 Antagonists, Non Sedating
  • Non-Sedating H1 Antihistamines
  • Third Generation H1 Antagonist
  • Third Generation H1 Antagonists

MeSH Record

Aspects Covered

22 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2003

MeSH Record

Previous Indexing

  • Benzhydryl Compounds (1982-2002)
  • Histamine H1 Antagonists (1982-2002)

MeSH Hierarchy

Tree Numbers

  1. D27.505.519w.625.375w.425w.400w.500
  2. D27.505.696.577.375w.425w.400w.500

AMA Style

References

  1. National Library of Medicine. Non-Sedating Histamine H1 Antagonists. Medical Subject Headings (MeSH). 2026. Unique ID D039563. http://id.nlm.nih.gov/mesh/2026/D039563
  2. Non-Sedating Histamine H1 Antagonists. In: Wikidata. https://www.wikidata.org/wiki/Q50430305