Chemicals and Drugs

Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.

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Synonyms

22 entry terms
  • Antagonists, Histamine H1
  • Antagonists, Histamine H1 Receptor
  • Antihistaminics, H1
  • Blockaders, Histamine H1 Receptor
  • H1 Receptor Blockaders
  • Histamine H1 Antagonist
  • Histamine H1 Blockers
  • Histamine H1 Receptor Antagonist
  • Histamine H1 Receptor Antagonists
  • Histamine H1 Receptor Blockaders
  • Receptor Blockaders, H1
  • Antagonist, Histamine H1
  • H1 Antagonist, Histamine
  • H1 Antagonists, Histamine
  • H1 Antihistaminics
  • Antihistamines, Classical
  • Antihistamines, Sedating
  • Antihistaminics, Classical
  • First Generation H1 Antagonists
  • Classical Antihistamines
  • Classical Antihistaminics
  • Sedating Antihistamines

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Aspects Covered

22 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

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Indexing Annotation

HISTAMINE H1 ANTAGONISTS, NON-SEDATING is also available

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History Note

95; was HISTAMINE H1 RECEPTOR BLOCKADERS 1977-94; was ANTIHISTAMINICS 1963-76; ANTIHISTAMINICS, CLASSICAL was ANTIHISTAMINICS see HISTAMINE H1 RECEPTOR BLOCKADERS 1977-90

MeSH Hierarchy

Tree Numbers

  1. D27.505.519w.625.375w.425w.400w
  2. D27.505.696.577.375w.425w.400w

MeSH Record

NLM Classification

QV 157

AMA Style

References

  1. National Library of Medicine. Histamine H1 Antagonists. Medical Subject Headings (MeSH). 2026. Unique ID D006634. http://id.nlm.nih.gov/mesh/2026/D006634
  2. Histamine H1 Antagonists. In: Wikipedia. https://en.wikipedia.org/wiki/H1_antagonist
  3. Histamine H1 Antagonists. In: Wikidata. https://www.wikidata.org/wiki/Q1328275