Chemicals and Drugs

Ataxin-1

A chromatin-binding factor that represses Notch signaling and associates with RNA. Expansion of the polyglutamine tract by expanded CAG repeats in the ATXN1 gene coding region is associated with SPINOCEREBELLAR ATAXIA 1.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A chromatin-binding factor that represses Notch signaling and associates with RNA. Expansion of the polyglutamine tract by expanded CAG repeats in the ATXN1 gene coding region is associated with SPINOCEREBELLAR ATAXIA 1.

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Synonyms

12 entry terms
  • Ataxin-1 Protein
  • Atxn-1 Protein
  • Atxn1 Protein
  • SCA1 Protein
  • Spinocerebellar Ataxia Type 1 Protein
  • Ataxin 1
  • Ataxin 1 Protein
  • Atxn 1 Protein
  • Protein, Ataxin-1
  • Protein, Atxn-1
  • Protein, Atxn1
  • Protein, SCA1

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Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2016 (1995)

MeSH Record

Previous Indexing

  • Nerve Tissue Proteins (1995-2015)
  • Nuclear Proteins (1995-2015)

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AMA Style

References

  1. National Library of Medicine. Ataxin-1. Medical Subject Headings (MeSH). 2026. Unique ID D000067696. http://id.nlm.nih.gov/mesh/2026/D000067696
  2. Ataxin-1. In: Wikidata. https://www.wikidata.org/wiki/Q4812916