Structured Summary
Abstract
A family of predominantly nuclear proteins that regulate gene transcription and protein degradation. The expansion of CAG trinucleotide repeats in genes that encode Ataxins is associated with SPINOCEREBELLAR ATAXIAS (SCA). In SCA patients, the number of CAG repeats correlates with the severity of disease and inversely correlates with the age of disease onset.
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Synonyms
11 entry terms
- Ataxin
- Ataxin Protein
- Ataxin Proteins
- Spinocerebellar Ataxia Protein
- Spinocerebellar Ataxia Proteins
- Ataxia Protein, Spinocerebellar
- Ataxia Proteins, Spinocerebellar
- Protein, Ataxin
- Protein, Spinocerebellar Ataxia
- Proteins, Ataxin
- Proteins, Spinocerebellar Ataxia
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Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
2016
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Previous Indexing
- Nerve Tissue Proteins (1995-2015)
- Nuclear Proteins (1995-2015)
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AMA Style
References
- National Library of Medicine. Ataxins. Medical Subject Headings (MeSH). 2026. Unique ID D000067528. http://id.nlm.nih.gov/mesh/2026/D000067528
- Ataxins. In: Wikipedia. https://en.wikipedia.org/wiki/Ataxin
- Ataxins. In: Wikidata. https://www.wikidata.org/wiki/Q4812915