Chemicals and Drugs

Baclofen

A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

36 entry terms
  • Baclophen
  • Chlorophenyl GABA
  • PCP-GABA
  • beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid
  • beta-(p-Chlorophenyl)-gamma-aminobutyric Acid
  • GABA, Chlorophenyl
  • Apo-Baclofen
  • Atrofen
  • Ba-34,647
  • Ba-34647
  • Baclofen AWD
  • Baclofène-Irex
  • Baclospas
  • CIBA-34,647-BA
  • Clofen
  • Gen-Baclofen
  • Genpharm
  • Lebic
  • Lioresal
  • Liorésal
  • Nu-Baclo
  • PMS-Baclofen
  • AWD, Baclofen
  • Apo Baclofen
  • ApoBaclofen
  • Ba34,647
  • Ba34647
  • Baclofène Irex
  • BaclofèneIrex
  • CIBA34,647BA
  • Gen Baclofen
  • GenBaclofen
  • Nu Baclo
  • NuBaclo
  • PMS Baclofen
  • PMSBaclofen

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

80(75); was see under AMINOBUTYRIC ACIDS 1975-79

MeSH Record

Previous Indexing

  • Aminobutyric Acids (1972-1974)
  • Chlorobenzenes (1974)

MeSH Hierarchy

Tree Number

  1. D02w.241w.081.114w.500.350w.100w

MeSH Record

NLM Classification

QV 140

AMA Style

References

  1. National Library of Medicine. Baclofen. Medical Subject Headings (MeSH). 2026. Unique ID D001418. http://id.nlm.nih.gov/mesh/2026/D001418
  2. Baclofen. In: Wikipedia. https://en.wikipedia.org/wiki/Baclofen
  3. Baclofen. In: Wikidata. https://www.wikidata.org/wiki/Q413717