Chemicals and Drugs

CASP8 and FADD-Like Apoptosis Regulating Protein

An APOPTOSIS-regulating protein that is structurally related to CASPASE 8 and competes with CASPASE 8 for binding to FAS ASSOCIATED DEATH DOMAIN PROTEIN. Two forms of CASP8 and FADD-like apoptosis regulating protein exist, a long form containing a caspase-like enzymatically inactive domain and a short form which lacks the caspase-like domain.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An APOPTOSIS-regulating protein that is structurally related to CASPASE 8 and competes with CASPASE 8 for binding to FAS ASSOCIATED DEATH DOMAIN PROTEIN. Two forms of CASP8 and FADD-like apoptosis regulating protein exist, a long form containing a caspase-like enzymatically inactive domain and a short form which lacks the caspase-like domain.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

15 entry terms
  • Casper Protein
  • FLICE-Inhibitory Protein
  • FLIP (Cellular)
  • CASP8 and FADD Like Apoptosis Regulating Protein
  • FLICE Inhibitory Protein
  • FLICE-Inhibitory Protein Long Form
  • FLICE-Inhibitory Protein Short Form
  • FLIP-L
  • FLIP-L Protein
  • FLIP-S
  • FLIP-S Protein
  • FLICE Inhibitory Protein Long Form
  • FLICE Inhibitory Protein Short Form
  • FLIP L Protein
  • FLIP S Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2007(1997)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.024w.285.024
  2. D12.644w.360.024w.500w.024
  3. D12.644w.360.075.421.024
  4. D12.776w.157w.057w.018.024
  5. D12.776w.476.075.421.024

AMA Style

References

  1. National Library of Medicine. CASP8 and FADD-Like Apoptosis Regulating Protein. Medical Subject Headings (MeSH). 2026. Unique ID D053446. http://id.nlm.nih.gov/mesh/2026/D053446
  2. CASP8 and FADD-Like Apoptosis Regulating Protein. In: Wikidata. https://www.wikidata.org/wiki/Q21151736