Chemicals and Drugs

CD3 Complex

Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).

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Synonyms

9 entry terms
  • Antigens, CD3
  • CD3 Antigen
  • CD3 Antigens
  • T3 Antigen
  • T3 Antigens
  • T3 Complex
  • Antigen, CD3
  • Antigen, T3
  • Antigens, T3

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018 (1993); use T3 ANTIGEN COMPLEX 1983-92; use ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE 1988-92

MeSH Record

Previous Indexing

  • Antigens (1983-1984)
  • Antigens, Differentiation, T-Lymphocyte (1988-1992)
  • Antigens, Surface (1983-1987)
  • Receptors, Antigen, T-Cell (1990-1992)

MeSH Hierarchy

Tree Numbers

  1. D23.050w.301.264.894.095w
  2. D23.101w.100.894.095w

AMA Style

References

  1. National Library of Medicine. CD3 Complex. Medical Subject Headings (MeSH). 2026. Unique ID D017252. http://id.nlm.nih.gov/mesh/2026/D017252
  2. CD3 Complex. In: Wikipedia. https://en.wikipedia.org/wiki/CD3_(immunology)
  3. CD3 Complex. In: Wikidata. https://www.wikidata.org/wiki/Q419458