Chemicals and Drugs

CD4 Immunoadhesins

Chimeric molecules resulting from the fusion of recombinant soluble CD4 to the Fc portion of immunoglobulins. These have potential use in the therapy of AIDS since they possess both the gp120-binding and HIV-blocking properties of rCD4 as well as the long plasma half-life and Fc receptor-binding functions of immunoglobulin.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Chimeric molecules resulting from the fusion of recombinant soluble CD4 to the Fc portion of immunoglobulins. These have potential use in the therapy of AIDS since they possess both the gp120-binding and HIV-blocking properties of rCD4 as well as the long plasma half-life and Fc receptor-binding functions of immunoglobulin.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

3 entry terms
  • Immunoadhesins, CD4
  • CD4-IgG
  • CD4 IgG

MeSH Record

Aspects Covered

23 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

92; was CD4 IMMUNOADHESIN (NM) 1989-91

MeSH Record

Previous Indexing

  • Antigens, CD (1990-1991)
  • Antigens, Differentiation, T-Lymphocyte (1989)
  • IgG (1989-1991)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.890w.200w.230w
  2. D12.644w.541.500.697.249w
  3. D12.776w.124w.486.485.538.500.249w
  4. D12.776w.124w.486.485.680.697.249w
  5. D12.776w.124w.790.651.538.500.249w
  6. D12.776w.124w.790.651.680.660.249w
  7. D12.776w.377w.715.548.538.500.249w
  8. D12.776w.377w.715.548.680.660.249w
  9. D12.776w.395w.550w.200w.230w
  10. D12.776w.543w.550w.200w.230w
  11. D12.776w.828.300.200w
  12. D23.050w.301.350w.230w

AMA Style

References

  1. National Library of Medicine. CD4 Immunoadhesins. Medical Subject Headings (MeSH). 2026. Unique ID D016860. http://id.nlm.nih.gov/mesh/2026/D016860
  2. CD4 Immunoadhesins. In: Wikipedia. https://en.wikipedia.org/wiki/CD4_immunoadhesin
  3. CD4 Immunoadhesins. In: Wikidata. https://www.wikidata.org/wiki/Q5009823