Chemicals and Drugs

CTLA-4 Antigen

An inhibitory T CELL receptor that is closely related to CD28 ANTIGEN. It has specificity for CD80 ANTIGEN and CD86 ANTIGEN and acts as a negative regulator of peripheral T cell function. CTLA-4 antigen is believed to play role in inducing PERIPHERAL TOLERANCE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An inhibitory T CELL receptor that is closely related to CD28 ANTIGEN. It has specificity for CD80 ANTIGEN and CD86 ANTIGEN and acts as a negative regulator of peripheral T cell function. CTLA-4 antigen is believed to play role in inducing PERIPHERAL TOLERANCE.

MeSH Record

Classification

Broader headings

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See Also

MeSH Record

Synonyms

12 entry terms
  • Antigens, CD152
  • CD152 Antigen
  • CTLA-4 Protein
  • Cytotoxic T-Lymphocyte Antigen 4
  • Cytotoxic T-Lymphocyte-Associated Antigen 4
  • Antigen, CD152
  • Antigen, CTLA-4
  • CD152 Antigens
  • CTLA 4 Antigen
  • CTLA 4 Protein
  • Cytotoxic T Lymphocyte Antigen 4
  • Cytotoxic T Lymphocyte Associated Antigen 4

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2012(1991)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.465.782
  2. D12.776w.543w.750w.705w.222.750
  3. D23.050w.301.264.894.158
  4. D23.101w.100.894.158

AMA Style

References

  1. National Library of Medicine. CTLA-4 Antigen. Medical Subject Headings (MeSH). 2026. Unique ID D060908. http://id.nlm.nih.gov/mesh/2026/D060908
  2. CTLA-4 Antigen. In: Wikidata. https://www.wikidata.org/wiki/Q24772115