Structured Summary
Abstract
Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
MeSH Record
Classification
Broader headings
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
7 entry terms
- Cardiac Glycoside
- Cardiotonic Steroid
- Cardiotonic Steroids
- Glycoside, Cardiac
- Glycosides, Cardiac
- Steroid, Cardiotonic
- Steroids, Cardiotonic
MeSH Record
Aspects Covered
26 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
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MeSH Record
NLM Classification
QV 153
AMA Style
References
- National Library of Medicine. Cardiac Glycosides. Medical Subject Headings (MeSH). 2026. Unique ID D002301. http://id.nlm.nih.gov/mesh/2026/D002301
- Cardiac Glycosides. In: Wikipedia. https://en.wikipedia.org/wiki/Cardiac_glycoside
- Cardiac Glycosides. In: Wikidata. https://www.wikidata.org/wiki/Q422238