Chemicals and Drugs

Cetirizine

A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.

Chemical Identity

Chemical Information

Molecular Formula
C21H25ClN2O3
Molecular Weight
388.9 g/mol
CAS Registry No.
83881-51-0
IUPAC Name
2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid
InChIKey
ZKLPARSLTMPFCP-UHFFFAOYSA-N
SMILES
C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl
MeSH Unique ID
D017332
Source
PubChem CID 2678

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

27 entry terms
  • (2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)acetic Acid
  • Alerlisin
  • Aller-Tec
  • Cetalerg
  • Ceterifug
  • Ceti TAD
  • Ceti-Puren
  • CetiLich
  • Cetiderm
  • Cetidura
  • Cetil von ct
  • Cetirigamma
  • Cetirizin AL
  • Cetirizin AZU
  • Cetirizin Basics
  • Cetirizine Dihydrochloride
  • Cetirlan
  • P-071
  • Reactine
  • Virlix
  • Voltric
  • Zetir
  • Zirtek
  • Zyrtec
  • Dihydrochloride, Cetirizine
  • P 071
  • P071

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

93; was CETIRIZINE (NM) 1987-92

MeSH Record

Previous Indexing

  • Hydroxyzine/analogs & derivatives (1987-1992)

MeSH Hierarchy

Tree Number

  1. D03w.383.606w.515w.200w

AMA Style

References

  1. National Library of Medicine. Cetirizine. Medical Subject Headings (MeSH). 2026. Unique ID D017332. http://id.nlm.nih.gov/mesh/2026/D017332
  2. Cetirizine. In: Wikipedia. https://en.wikipedia.org/wiki/Cetirizine
  3. Cetirizine. In: Wikidata. https://www.wikidata.org/wiki/Q423075
  4. Cetirizine. In: PubChem Compound. CID 2678. https://pubchem.ncbi.nlm.nih.gov/compound/2678