Chemicals and Drugs

Chlormethiazole

A sedative and anticonvulsant often used in the treatment of alcohol withdrawal. Chlormethiazole has also been proposed as a neuroprotective agent. The mechanism of its therapeutic activity is not entirely clear, but it does potentiate GAMMA-AMINOBUTYRIC ACID receptors response and it may also affect glycine receptors.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A sedative and anticonvulsant often used in the treatment of alcohol withdrawal. Chlormethiazole has also been proposed as a neuroprotective agent. The mechanism of its therapeutic activity is not entirely clear, but it does potentiate GAMMA-AMINOBUTYRIC ACID receptors response and it may also affect glycine receptors.

Chemical Identity

Chemical Information

Molecular Formula
C6H8ClNS
Molecular Weight
161.65 g/mol
CAS Registry No.
533-45-9
IUPAC Name
5-(2-chloroethyl)-4-methyl-1,3-thiazole
InChIKey
PCLITLDOTJTVDJ-UHFFFAOYSA-N
SMILES
CC1=C(SC=N1)CCCl
MeSH Unique ID
D002719
Source
PubChem CID 10783

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

2 entry terms
  • Clomethiazole
  • Distraneurin

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

68; CHLORETHIAZOLE was see CHLORMETHAZOLE 1975-95

MeSH Record

Previous Indexing

  • Hypnotics and Sedatives (1966-1967)
  • Thiazoles (1966-1967)

MeSH Hierarchy

Tree Numbers

  1. D02w.886w.675.180w
  2. D03w.383.129w.708.180w

AMA Style

References

  1. National Library of Medicine. Chlormethiazole. Medical Subject Headings (MeSH). 2026. Unique ID D002719. http://id.nlm.nih.gov/mesh/2026/D002719
  2. Chlormethiazole. In: Wikipedia. https://en.wikipedia.org/wiki/Clomethiazole
  3. Chlormethiazole. In: Wikidata. https://www.wikidata.org/wiki/Q417178
  4. Chlormethiazole. In: PubChem Compound. CID 10783. https://pubchem.ncbi.nlm.nih.gov/compound/10783