Chemicals and Drugs

Chlorpromazine

The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.

Chemical Identity

Chemical Information

Molecular Formula
C17H19ClN2S
Molecular Weight
318.9 g/mol
CAS Registry No.
50-53-3
IUPAC Name
3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
InChIKey
ZPEIMTDSQAKGNT-UHFFFAOYSA-N
SMILES
CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
MeSH Unique ID
D002746
Source
PubChem CID 2726

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

10 entry terms
  • Aminazine
  • Chlorazine
  • Chlordelazine
  • Chlorpromazine Hydrochloride
  • Contomin
  • Fenactil
  • Largactil
  • Propaphenin
  • Thorazine
  • Hydrochloride, Chlorpromazine

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

/adv eff-pois-tox was CHLORPROMAZINE TOXICOLOGY 1963-65

MeSH Hierarchy

Tree Numbers

  1. D02w.886w.369.198w
  2. D03w.633.300.783.198w

AMA Style

References

  1. National Library of Medicine. Chlorpromazine. Medical Subject Headings (MeSH). 2026. Unique ID D002746. http://id.nlm.nih.gov/mesh/2026/D002746
  2. Chlorpromazine. In: Wikipedia. https://en.wikipedia.org/wiki/Chlorpromazine
  3. Chlorpromazine. In: Wikidata. https://www.wikidata.org/wiki/Q407972
  4. Chlorpromazine. In: PubChem Compound. CID 2726. https://pubchem.ncbi.nlm.nih.gov/compound/2726