Chemicals and Drugs

Cholesterol 7-alpha-Hydroxylase

A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

14 entry terms
  • CYP 7
  • CYP 7A
  • CYP7
  • CYP7A
  • Cholesterol 7-alpha-Monooxygenase
  • Cholesterol 7alpha-Hydroxylase
  • Cholesterol-7-Hydroxylase
  • Cytochrome P-450 CYP7
  • Cytochrome P450 7
  • Cholesterol 7 Hydroxylase
  • Cholesterol 7 alpha Hydroxylase
  • Cholesterol 7 alpha Monooxygenase
  • Cholesterol 7alpha Hydroxylase
  • Cytochrome P 450 CYP7

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003 (1975)

MeSH Record

Previous Indexing

  • Cholesterol (1974)
  • Steroid Hydroxylases (1974)

MeSH Hierarchy

Tree Numbers

  1. D08.244w.453w.890.500
  2. D08.244w.453w.915w.200
  3. D08.811w.682w.690w.708.170w.890.500
  4. D08.811w.682w.690w.708.170w.915w.200
  5. D12.776w.422w.220w.453w.890.500
  6. D12.776w.422w.220w.453w.915w.200

MeSH Record

NLM Classification

QU 140

AMA Style

References

  1. National Library of Medicine. Cholesterol 7-alpha-Hydroxylase. Medical Subject Headings (MeSH). 2026. Unique ID D002790. http://id.nlm.nih.gov/mesh/2026/D002790
  2. Cholesterol 7-alpha-Hydroxylase. In: Wikidata. https://www.wikidata.org/wiki/Q5104318