Chemicals and Drugs

Cimetidine

A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.

Chemical Identity

Chemical Information

Molecular Formula
C10H16N6S
Molecular Weight
252.34 g/mol
CAS Registry No.
51481-61-9
IUPAC Name
1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine
InChIKey
AQIXAKUUQRKLND-UHFFFAOYSA-N
SMILES
CC1=C(N=CN1)CSCCNC(=NC)NC#N
MeSH Unique ID
D002927
Source
PubChem CID 2756

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

17 entry terms
  • N-Cyano-N'-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)guanidine
  • Altramet
  • Biomet
  • Biomet400
  • Cimetidine HCl
  • Cimetidine Hydrochloride
  • Eureceptor
  • Histodil
  • SK&F-92334
  • SKF-92334
  • Tagamet
  • HCl, Cimetidine
  • Hydrochloride, Cimetidine
  • SK&F 92334
  • SK&F92334
  • SKF 92334
  • SKF92334

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

84(78); was see under GUANIDINES 1978-83

MeSH Record

Previous Indexing

  • Guanidines (1966-1977)
  • Imidazoles (1966-1977)

MeSH Hierarchy

Tree Numbers

  1. D02w.078w.370.200w
  2. D03w.383.129w.308.130w

MeSH Record

NLM Classification

QV 157

AMA Style

References

  1. National Library of Medicine. Cimetidine. Medical Subject Headings (MeSH). 2026. Unique ID D002927. http://id.nlm.nih.gov/mesh/2026/D002927
  2. Cimetidine. In: Wikipedia. https://en.wikipedia.org/wiki/Cimetidine
  3. Cimetidine. In: Wikidata. https://www.wikidata.org/wiki/Q409492
  4. Cimetidine. In: PubChem Compound. CID 2756. https://pubchem.ncbi.nlm.nih.gov/compound/2756