Structured Summary
Abstract
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Chemical Identity
Chemical Information
- Molecular Formula
- Cl2H6N2Pt
- Molecular Weight
- 300.05 g/mol
- CAS Registry No.
- 15663-27-1
- IUPAC Name
- azane;dichloroplatinum
- InChIKey
- LXZZYRPGZAFOLE-UHFFFAOYSA-L
- SMILES
- N.N.Cl[Pt]Cl
- MeSH Unique ID
- D002945
- Source
- PubChem CID 5460033
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
14 entry terms
- Dichlorodiammineplatinum
- Platinum Diamminodichloride
- cis-Diamminedichloroplatinum
- cis-Diamminedichloroplatinum(II)
- cis-Dichlorodiammineplatinum(II)
- cis-Platinum
- Diamminodichloride, Platinum
- cis Diamminedichloroplatinum
- cis Platinum
- Biocisplatinum
- NSC-119875
- Platidiam
- Platino
- Platinol
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
84(81); was see under DIAMMONIUM CHLOROPLATINUM COMPOUNDS 1981-83; was PLATINUM DIAMMINODICHLORIDE see under DIAMMONIUM CHLOROPLATINUM COMPOUNDS 1974-80; DIAMMONIUM CHLOROPLATINUM COMPOUNDS was heading 1974-83
MeSH Record
Previous Indexing
- Amines (1966-1973)
- Ammonium Compounds (1966-1973)
- Chlorides (1966-1973)
- Platinum (1966-1973)
MeSH Hierarchy
Tree Numbers
MeSH Record
NLM Classification
QV 269
AMA Style
References
- National Library of Medicine. Cisplatin. Medical Subject Headings (MeSH). 2026. Unique ID D002945. http://id.nlm.nih.gov/mesh/2026/D002945
- Cisplatin. In: Wikipedia. https://en.wikipedia.org/wiki/Cisplatin
- Cisplatin. In: Wikidata. https://www.wikidata.org/wiki/Q412415
- Cisplatin. In: PubChem Compound. CID 5460033. https://pubchem.ncbi.nlm.nih.gov/compound/5460033