Chemicals and Drugs

Clemastine

A histamine H1 antagonist used as the hydrogen fumarate in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A histamine H1 antagonist used as the hydrogen fumarate in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.

Chemical Identity

Chemical Information

Molecular Formula
C21H26ClNO
Molecular Weight
343.9 g/mol
CAS Registry No.
15686-51-8
IUPAC Name
(2R)-2-[2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine
InChIKey
YNNUSGIPVFPVBX-NHCUHLMSSA-N
SMILES
C[C@@](C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCC[C@H]3CCCN3C
MeSH Unique ID
D002974
Source
PubChem CID 26987

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • 2-(2-(1-(4-Chlorophenyl)-1-phenylethoxy)ethyl)-1-methylpyrrolidine
  • Meclastine
  • Mecloprodin
  • Clemastine Fumarate
  • HS-592
  • Tavegyl
  • Tavist
  • HS 592
  • HS592

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(79); was see under PYRROLIDINES 1979-90; was MECLASTINE see under PYRROLIDINES 1973-78 (Prov 1973-74)

MeSH Record

Previous Indexing

  • Histamine H1 Receptor Blockaders (1966-1972)
  • Pyrrolidines (1966-1972)

MeSH Hierarchy

Tree Number

  1. D03w.383.773.165w

AMA Style

References

  1. National Library of Medicine. Clemastine. Medical Subject Headings (MeSH). 2026. Unique ID D002974. http://id.nlm.nih.gov/mesh/2026/D002974
  2. Clemastine. In: Wikipedia. https://en.wikipedia.org/wiki/Clemastine
  3. Clemastine. In: Wikidata. https://www.wikidata.org/wiki/Q418145
  4. Clemastine. In: PubChem Compound. CID 26987. https://pubchem.ncbi.nlm.nih.gov/compound/26987