Chemicals and Drugs

Codeine

An opioid analgesic related to MORPHINE but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An opioid analgesic related to MORPHINE but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough.

Chemical Identity

Chemical Information

Molecular Formula
C18H21NO3
Molecular Weight
299.4 g/mol
CAS Registry No.
76-57-3
IUPAC Name
(4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
InChIKey
OROGSEYTTFOCAN-DNJOTXNNSA-N
SMILES
CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](C=C4)O
MeSH Unique ID
D003061
Source
PubChem CID 5284371

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

6 entry terms
  • Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-
  • N-Methylmorphine
  • N Methylmorphine
  • Ardinex
  • Codeine Phosphate
  • Isocodeine

MeSH Record

Aspects Covered

27 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

codeine derivatives = CODEINE /analogs

MeSH Record

History Note

CODEINE DERIVATIVES was see under CODEINE 1975-77, was see under MORPHINANS 1969-74

MeSH Hierarchy

Tree Numbers

  1. D03w.132w.577.249.562.149w
  2. D03w.605.497.607.204w
  3. D03w.633.400.686.607.204w
  4. D04w.615w.723w.795.576.149w

AMA Style

References

  1. National Library of Medicine. Codeine. Medical Subject Headings (MeSH). 2026. Unique ID D003061. http://id.nlm.nih.gov/mesh/2026/D003061
  2. Codeine. In: Wikipedia. https://en.wikipedia.org/wiki/Codeine
  3. Codeine. In: Wikidata. https://www.wikidata.org/wiki/Q174723
  4. Codeine. In: PubChem Compound. CID 5284371. https://pubchem.ncbi.nlm.nih.gov/compound/5284371