Chemicals and Drugs

Colistin

Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.

Chemical Identity

Chemical Information

Molecular Formula
C52H98N16O13
Molecular Weight
1155.4 g/mol
IUPAC Name
N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(6R,9S,12R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-5-methylheptanamide
InChIKey
YKQOSKADJPQZHB-BRLOSWAASA-N
SMILES
CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)C(NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)C(NC(=O)[C@@H](NC1=O)CCN)CC(C)C)CC(C)C)CCN)CCN)[C@@H](C)O
MeSH Unique ID
D003091
Source
PubChem CID 131704173

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

7 entry terms
  • Colimycin
  • Colisticin
  • Polymyxin E
  • Colistin Sulfate
  • Coly-Mycin
  • Totazina
  • Sulfate, Colistin

MeSH Record

Aspects Covered

26 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Hierarchy

Tree Numbers

  1. D04w.345w.566w.780w.110w
  2. D10w.477w.750w.110w
  3. D12.644w.050.600w.110w
  4. D12.644w.066w.500.600w.110w
  5. D12.644w.641w.780w.110w
  6. D12.776w.543w.695w.054.600w.110w

MeSH Record

NLM Classification

QV 350

AMA Style

References

  1. National Library of Medicine. Colistin. Medical Subject Headings (MeSH). 2026. Unique ID D003091. http://id.nlm.nih.gov/mesh/2026/D003091
  2. Colistin. In: Wikipedia. https://en.wikipedia.org/wiki/Colistin
  3. Colistin. In: Wikidata. https://www.wikidata.org/wiki/Q418946
  4. Colistin. In: PubChem Compound. CID 131704173. https://pubchem.ncbi.nlm.nih.gov/compound/131704173