Chemicals and Drugs

Pore Forming Cytotoxic Proteins

Proteins secreted from an organism which form membrane-spanning pores in target cells to destroy them. This is in contrast to PORINS and MEMBRANE TRANSPORT PROTEINS that function within the synthesizing organism and COMPLEMENT immune proteins. These pore forming cytotoxic proteins are a form of primitive cellular defense which are also found in human LYMPHOCYTES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Proteins secreted from an organism which form membrane-spanning pores in target cells to destroy them. This is in contrast to PORINS and MEMBRANE TRANSPORT PROTEINS that function within the synthesizing organism and COMPLEMENT immune proteins. These pore forming cytotoxic proteins are a form of primitive cellular defense which are also found in human LYMPHOCYTES.

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30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

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History Note

2007

MeSH Record

Previous Indexing

  • Porins (1980-2006)

MeSH Hierarchy

Tree Number

  1. D12.776w.543w.695w

AMA Style

References

  1. National Library of Medicine. Pore Forming Cytotoxic Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D052899. http://id.nlm.nih.gov/mesh/2026/D052899
  2. Pore Forming Cytotoxic Proteins. In: Wikipedia. https://en.wikipedia.org/wiki/Pore-forming_toxin
  3. Pore Forming Cytotoxic Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q7230047