Chemicals and Drugs

Complement C1 Inhibitor Protein

An endogenous 105-kDa plasma glycoprotein produced primarily by the LIVER and MONOCYTES. It inhibits a broad spectrum of proteases, including the COMPLEMENT C1R and the COMPLEMENT C1S proteases of the CLASSICAL COMPLEMENT PATHWAY, and the MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. C1-INH-deficient individuals suffer from HEREDITARY ANGIOEDEMA TYPES I AND II.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An endogenous 105-kDa plasma glycoprotein produced primarily by the LIVER and MONOCYTES. It inhibits a broad spectrum of proteases, including the COMPLEMENT C1R and the COMPLEMENT C1S proteases of the CLASSICAL COMPLEMENT PATHWAY, and the MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. C1-INH-deficient individuals suffer from HEREDITARY ANGIOEDEMA TYPES I AND II.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

11 entry terms
  • C1 Esterase Inhibitor
  • C1-INH Protein
  • C1-Inhibitor Protein
  • Complement C1-Inhibitor Protein
  • Plasma Protease C1 Inhibitor
  • SERPING1
  • Serpin Family G Member 1
  • Serpin G1
  • C1 INH Protein
  • C1 Inhibitor Protein
  • Esterase Inhibitor, C1

MeSH Record

Aspects Covered

27 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

do not confuse with COMPLEMENT C1 INACTIVATOR PROTEINS

MeSH Record

History Note

2006; for C1 ESTERASE INHIBITOR use COMPLEMENT C1 INACTIVATOR PROTEINS 1970-2005

MeSH Record

Previous Indexing

  • Complement C1 Inactivator Proteins (1970-2005)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.780w
  2. D12.644w.861w.140.500w
  3. D12.776w.124w.486.274.920.250.500w
  4. D12.776w.395w.320w
  5. D12.776w.872w.140.500w

AMA Style

References

  1. National Library of Medicine. Complement C1 Inhibitor Protein. Medical Subject Headings (MeSH). 2026. Unique ID D050718. http://id.nlm.nih.gov/mesh/2026/D050718
  2. Complement C1 Inhibitor Protein. In: Wikipedia. https://en.wikipedia.org/wiki/C1-inhibitor
  3. Complement C1 Inhibitor Protein. In: Wikidata. https://www.wikidata.org/wiki/Q416510