Structured Summary
Abstract
C5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT C5A and COMPLEMENT C5B. The smaller fragment C5a is an ANAPHYLATOXIN and mediator of inflammatory process. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the MEMBRANE ATTACK COMPLEX.
MeSH Record
Classification
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
15 entry terms
- C5 Complement
- Complement 5
- Complement Component 5
- C5, Complement
- Complement, C5
- Component 5, Complement
- Complement C5, Precursor
- Precursor C5
- Pro-C5
- Pro-complement 5
- C5, Precursor
- C5, Precursor Complement
- Precursor Complement C5
- Pro C5
- Pro complement 5
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2006 (1975)
MeSH Record
Previous Indexing
- Complement (1968-1974)
- Histamine Liberation (1966-1974)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Complement C5. Medical Subject Headings (MeSH). 2026. Unique ID D003182. http://id.nlm.nih.gov/mesh/2026/D003182
- Complement C5. In: Wikipedia. https://en.wikipedia.org/wiki/Complement_component_5
- Complement C5. In: Wikidata. https://www.wikidata.org/wiki/Q426181