Chemicals and Drugs

Complement Factor H

An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

2 entry terms
  • Factor H
  • Factor H, Complement

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

93; was COMPLEMENT FACTOR H (NM) 1978-92

MeSH Record

Previous Indexing

  • Beta Globulins (1978-1979)
  • Complement 3b Inactivators (1980-1992)
  • Glycoproteins (1978-1979)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.124w.486.274.920.325.200
  2. D12.776w.124w.790.223w.200
  3. D12.776w.377w.715.182w.200

AMA Style

References

  1. National Library of Medicine. Complement Factor H. Medical Subject Headings (MeSH). 2026. Unique ID D017242. http://id.nlm.nih.gov/mesh/2026/D017242
  2. Complement Factor H. In: Wikidata. https://www.wikidata.org/wiki/Q581194