Structured Summary
Abstract
A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein, respectively. It is a 66-kDa glycoprotein that converts C3b to inactivated C3b (iC3b) followed by the release of two fragments, C3c (150-kDa) and C3dg (41-kDa). It was formerly called KAF, C3bINF, or enzyme 3b inactivator.
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Classification
Broader headings
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
14 entry terms
- C3b Inactivator
- C3b-C4b Inactivator
- C4b-C3b-INA
- C4bC3bINA
- Complement 3b-Complement 4b Inactivator
- Complement C4b-C3b Inactivator
- C3b C4b Inactivator
- C4b C3b INA
- C4b-C3b Inactivator, Complement
- Complement 3b Complement 4b Inactivator
- Complement C4b C3b Inactivator
- Inactivator, C3b
- Inactivator, C3b-C4b
- Inactivator, Complement C4b-C3b
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
Indexing Annotation
do not confuse with FACTOR I see FIBRINOGEN
MeSH Record
History Note
93; was FACTOR I, C 3B INACTIVATOR (NM) 1983-92
MeSH Record
Previous Indexing
- Peptide Peptidohydrolases (1983-1987)
- Serine Proteinases (1988-1992)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Complement Factor I. Medical Subject Headings (MeSH). 2026. Unique ID D017244. http://id.nlm.nih.gov/mesh/2026/D017244
- Complement Factor I. In: Wikidata. https://www.wikidata.org/wiki/Q5156413