Structured Summary
Abstract
A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding domain known as the runt domain. They can act as both activators and repressors of expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression.
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Classification
Broader headings
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Synonyms
8 entry terms
- Acute Myeloid Leukemia Proteins
- Core Binding Factor alpha Proteins
- PEBP2A Transcription Factors
- Polyomavirus Enhancer A Binding Protein 2
- Polyomavirus Enhancer Binding Protein 2, Alpha Subunit
- Runt Domain Factor
- Runx Proteins
- Transcription Factors, PEBP2A
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Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2006(1987)
MeSH Record
Previous Indexing
- DNA-Binding Proteins (1987-2005)
- Neoplasm Proteins (1997-2005)
- Transcription Factors (1987-2005)
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AMA Style
References
- National Library of Medicine. Core Binding Factor alpha Subunits. Medical Subject Headings (MeSH). 2026. Unique ID D050657. http://id.nlm.nih.gov/mesh/2026/D050657
- Core Binding Factor alpha Subunits. In: Wikidata. https://www.wikidata.org/wiki/Q78119037