Structured Summary
Abstract
Rare congenital disorder with multiple anomalies including: characteristic dysmorphic craniofacial features, musculoskeletal abnormalities, neurocognitive delay, and high prevalence of cancer. Germline mutations in H-Ras protein can cause Costello syndrome. Costello syndrome shows early phenotypic overlap with other disorders that involve MAP KINASE SIGNALING SYSTEM (e.g., NOONAN SYNDROME and cardiofaciocutaneous syndrome).
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Classification
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Synonyms
9 entry terms
- FCS Syndrome
- Faciocutaneoskeletal Syndrome
- FCS Syndromes
- Faciocutaneoskeletal Syndromes
- Syndrome, Costello
- Syndrome, FCS
- Syndrome, Faciocutaneoskeletal
- Syndromes, FCS
- Syndromes, Faciocutaneoskeletal
MeSH Record
Aspects Covered
34 allowable subheadings
Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.
MeSH Record
History Note
2010
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AMA Style
References
- National Library of Medicine. Costello Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D056685. http://id.nlm.nih.gov/mesh/2026/D056685
- Costello Syndrome. In: Wikipedia. https://en.wikipedia.org/wiki/Costello_syndrome
- Costello Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q1136492