Chemicals and Drugs

Cyclin-Dependent Kinase Inhibitor p16

A product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member of the INK4 CYCLIN-DEPENDENT KINASE INHIBITORS. This protein is produced from the alpha mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced beta transcript, is TUMOR SUPPRESSOR PROTEIN P14ARF. Both p16 gene products have tumor suppressor functions.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member of the INK4 CYCLIN-DEPENDENT KINASE INHIBITORS. This protein is produced from the alpha mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced beta transcript, is TUMOR SUPPRESSOR PROTEIN P14ARF. Both p16 gene products have tumor suppressor functions.

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Synonyms

15 entry terms
  • CDKN2 Protein
  • CDKN2A Protein
  • Cdk4-Associated Protein p16
  • Cyclin-Dependent Kinase Inhibitor-2A
  • INK4A Protein
  • MTS1 Protein
  • Multiple Tumor Suppressor-1
  • p16(INK4A)
  • p16INK4 Protein
  • p16INK4A Protein
  • Cdk4 Associated Protein p16
  • Cyclin Dependent Kinase Inhibitor 2A
  • Cyclin Dependent Kinase Inhibitor p16
  • Multiple Tumor Suppressor 1
  • Protein, INK4A

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Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2006(1994)

MeSH Record

Previous Indexing

  • Carrier Proteins (1994-1997)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.225w.200w
  2. D12.776w.167.187w.200w
  3. D12.776w.476.225w.200w
  4. D12.776w.624.776.355w.200w

AMA Style

References

  1. National Library of Medicine. Cyclin-Dependent Kinase Inhibitor p16. Medical Subject Headings (MeSH). 2026. Unique ID D019941. http://id.nlm.nih.gov/mesh/2026/D019941
  2. Cyclin-Dependent Kinase Inhibitor p16. In: Wikipedia. https://en.wikipedia.org/wiki/P16
  3. Cyclin-Dependent Kinase Inhibitor p16. In: Wikidata. https://www.wikidata.org/wiki/Q416259