Structured Summary
Abstract
A major cytochrome P-450 enzyme which is inducible by PHENOBARBITAL in both the LIVER and SMALL INTESTINE. It is active in the metabolism of compounds like pentoxyresorufin, TESTOSTERONE, and ANDROSTENEDIONE. This enzyme, encoded by CYP2B1 gene, also mediates the activation of CYCLOPHOSPHAMIDE and IFOSFAMIDE to MUTAGENS.
MeSH Record
Classification
Broader headings
Related Concepts
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MeSH Record
Synonyms
15 entry terms
- 7-Benzyloxyresorufin O-Dealkylase
- 7-Pentylresorufin O-Depentylase
- BROD
- Benzyloxyresorufin O-Dealkylase
- CYP 2B1
- CYP2B1
- Cytochrome P450 2B1
- PROD
- Pentoxyresorufin O-Dealkylase
- 7 Benzyloxyresorufin O Dealkylase
- 7 Pentylresorufin O Depentylase
- Benzyloxyresorufin O Dealkylase
- Cytochrome P 450 CYP2B1
- O-Dealkylase, Pentoxyresorufin
- Pentoxyresorufin O Dealkylase
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
Indexing Annotation
do not confuse with other cytochrome P-450 CYP's
MeSH Record
History Note
97; was PENTOXYRESORUFIN O-DEALKYLASE (NM) 1985-96
MeSH Record
Previous Indexing
- Cytochrome P-450 (1985-1996)
- Oxidoreductases (1985-1996)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Cytochrome P-450 CYP2B1. Medical Subject Headings (MeSH). 2026. Unique ID D019362. http://id.nlm.nih.gov/mesh/2026/D019362
- Cytochrome P-450 CYP2B1. In: Wikidata. https://www.wikidata.org/wiki/Q76945297