Structured Summary
Abstract
A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population.
MeSH Record
Classification
Broader headings
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MeSH Record
Synonyms
20 entry terms
- CYP 2D6
- CYP2D6
- Cytochrome P450 2D6
- Debrisoquine 4-Hydroxylase
- Debrisoquine 4-Monooxygenase
- Debrisoquine Hydroxylase
- Imipramine 2-Hydroxylase
- Sparteine Monooxygenase
- 2-Hydroxylase, Imipramine
- 4-Hydroxylase, Debrisoquine
- 4-Monooxygenase, Debrisoquine
- CYP2D6, Cytochrome P-450
- Cytochrome P 450 CYP2D6
- Debrisoquine 4 Hydroxylase
- Debrisoquine 4 Monooxygenase
- Hydroxylase, Debrisoquine
- Imipramine 2 Hydroxylase
- Monooxygenase, Sparteine
- P-450 CYP2D6, Cytochrome
- P450 2D6, Cytochrome
MeSH Record
Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
97; was DEBRISOQUINE 4-HYDROXYLASE (NM) 1982-96
MeSH Record
Previous Indexing
- Cytochrome P-450 (1975-1996)
- Hydroxylases (1979-1996)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Cytochrome P-450 CYP2D6. Medical Subject Headings (MeSH). 2026. Unique ID D019389. http://id.nlm.nih.gov/mesh/2026/D019389
- Cytochrome P-450 CYP2D6. In: Wikipedia. https://en.wikipedia.org/wiki/CYP2D6
- Cytochrome P-450 CYP2D6. In: Wikidata. https://www.wikidata.org/wiki/Q3271142