Chemicals and Drugs

DCC Receptor

A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2 domains and six membrane proximal (C-terminal) fibronectin type III domains. It is expressed primarily in the nerve axons and differentiated intestinal cells and is required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however, it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor. DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC gene are observed in tumor metastases and the protein is not expressed in undifferentiated COLORECTAL CARCINOMA cells.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2 domains and six membrane proximal (C-terminal) fibronectin type III domains. It is expressed primarily in the nerve axons and differentiated intestinal cells and is required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however, it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor. DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC gene are observed in tumor metastases and the protein is not expressed in undifferentiated COLORECTAL CARCINOMA cells.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

6 entry terms
  • DCC Tumor Suppressor Protein
  • DCC-Netrin-1 Receptor
  • Deleted in Colorectal Carcinoma Protein
  • DCC Netrin 1 Receptor
  • Receptor, DCC
  • Receptor, DCC-Netrin-1

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Receptors, Cell Surface (2005-2017)
  • Tumor Suppressor Proteins (2005-2017)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.075.413
  2. D12.776w.476.075.413
  3. D12.776w.543w.750w.003.500
  4. D12.776w.624.776.021

AMA Style

References

  1. National Library of Medicine. DCC Receptor. Medical Subject Headings (MeSH). 2026. Unique ID D000075389. http://id.nlm.nih.gov/mesh/2026/D000075389
  2. DCC Receptor. In: Wikidata. https://www.wikidata.org/wiki/Q24770709